Satellite DNA fragility accompanies complex genome rearrangements and ecDNA oncogene amplification in canine osteosarcomas
Feyza Yilmaz, Wonyoung Kong, Sabriya A. Syed, Francis H. O’Neill, Jody T Lombardi, Patrick Kwok Shing Ng, Ching C. Lau, Charles Lee
This study identifies satellite DNA fragility and ecDNA oncogene amplification in canine osteosarcomas using long-read sequencing, revealing genomic instability mechanisms relevant to human cancer.
bioRxiv · Dec 31, 2025 · PreprintGenomics