Wylie Stroberg

On the estimation errors of KM and V from time-course experiments using the Michaelis-Menten equation

The paper analyzes the conditions under which the Michaelis-Menten equation can accurately estimate KM and V from progress curve data, showing that initial substrate and enzyme concentrations must be carefully controlled.

On the validity and errors of the pseudo-first-order kinetics in ligand-receptor binding

The paper analyzes the validity and errors of pseudo-first-order kinetics in ligand-receptor binding, showing that the two interpretations of validity are distinct and can lead to large errors in kinetic constant estimation.