Cancer BiologybioRxiv
KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
A. D'oto, J. Fang, H. Jin…·J. YANG
This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.
DOI 10.1038/s41467-021-27502-2