KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
A. D'oto, J. Fang, H. Jin, B. Xu, S. Singh, A. Mullasseril, V. Jones, X. Von Butler, B. Cooke, D. Hu, J. Shohet, A. Murphy, A. Davidoff, J. YANG
This study shows KDM6B promotes oncogenic CDK4/6-pRB-E2F pathway activation in neuroblastoma by maintaining enhancer activity, and its inhibition correlates with poor patient survival.
bioRxiv · Jul 2, 2020Cancer Biology