Activation of IRF7/ISG15 axis in microglia inhibits NLRP3 Expression and Improves the Prognosis of Ischemia/Reperfusion in Mice
Hao Yan, Xiangyang Cao, Meng Ma, Qin He, Feiyang Li, Ruxiang Xu, Yangyang Wang, Yi Zheng, Jing Yang, Ying Xiao
This study shows that activating the IRF7/ISG15 axis in microglia reduces NLRP3 expression and improves ischemia/reperfusion outcomes in mice, with ISG15 having stronger neuroprotective effects.
bioRxiv · Nov 8, 2025 · PreprintNeuroscience