NeurosciencebioRxivPreprint
Activation of IRF7/ISG15 axis in microglia inhibits NLRP3 Expression and Improves the Prognosis of Ischemia/Reperfusion in Mice
Hao Yan, Xiangyang Cao, Meng Ma…·Ying Xiao
This study shows that activating the IRF7/ISG15 axis in microglia reduces NLRP3 expression and improves ischemia/reperfusion outcomes in mice, with ISG15 having stronger neuroprotective effects.
DOI 10.1101/2025.11.08.687338