In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9
Yong Kang Tao, Cenfeng Chu, Zhenzhe Cheng, Yilin Sun, Ying Chen, Heng Zhang, Shuyue Bao, Boyu Yang, Baoyi Feng, Xianyu Huang, Yao Lu, Qiuxiang Yang, Xuegao Mao, Qifang Zhou, Chenxi Jin, , Hao Wu
This study identifies AAV-WM04 as a highly efficient and safe gene delivery vector for targeting inner hair cells in the cochlea, showing effectiveness in mice and non-human primates for treating hereditary hearing loss.
bioRxiv · Mar 11, 2026 · PreprintGenetics