Beclin-1 restrains aldosterone signaling via autophagic degradation of the mineralocorticoid receptor to protect against cardiovascular injury
Lei Wang, Wenyi Jiang, Hao-Tian Zhang, Xiao-Wei Sun, Ya-Mai Gao, Koji Murao, Guo‐Xing Zhang
This study shows Beclin-1 inhibits aldosterone signaling by degrading the mineralocorticoid receptor via autophagy, reducing cardiovascular damage in mice.
bioRxiv · Jun 5, 2026 · PreprintMolecular Biology