Cryo-electron microscopy ensemble optimization using individual particles and physical constraints
David Silva-Sánchez, Alison Berezuk, Xing Zhu, Erik H. Thiede, Roy R. Lederman, Pilar Cossio
This paper introduces a Bayesian optimization method for cryo-EM ensemble optimization, directly inferring structures and population weights from particle images and physical constraints.
Journal of Chemical Theory and Computation · May 11, 2026Peer-reviewedBiophysics