Roy R. Lederman

The paper argues that atomic models in cryo-EM should be fitted to particle images rather than volumes, showing that weighted volumes can achieve similar results and proposing an implementation in existing software.

This paper introduces a Bayesian optimization method for cryo-EM ensemble optimization, directly inferring structures and population weights from particle images and physical constraints.

The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.