Structural and Dynamic Basis of TREM2--DAP12 Stabilization by Small-Molecule Agonist VG-3927
Fanyu Zhao, Wei Xia, Xintai Zhang, Xue Wu, Junxiao Ding, Xiangyue Li, John Z.H. Zhang
This study investigates how the small-molecule agonist VG-3927 stabilizes the TREM2-DAP12 complex by binding within a transmembrane cavity and altering its conformation.
bioRxiv · Jun 23, 2026 · PreprintMolecular Biology