Wei Xia

This study investigates how the small-molecule agonist VG-3927 stabilizes the TREM2-DAP12 complex by binding within a transmembrane cavity and altering its conformation.

SAKE-PP improves PPI model evaluation by predicting interface RMSD without native references, outperforming AF3 on docking decoys and antibody-antigen complexes.

The paper develops two GPCR-specific models, DeepGPCR_BC and DeepGPCR_RG, for binary classification and affinity prediction of ligand interactions, achieving better performance than existing tools.

ChemXTree improves small-molecule drug discovery by integrating tree-based algorithms with a graph model, showing superior performance in feature optimization on benchmark datasets.