Disentangling phenotype scale, amplification, and effect heterogeneity underlying polygenic GxE architecture of complex traits
Zhengtong Liu, Aakarsh Anand, Xinyue Qie, Manuela Costantino, Moonseong 정문성Jeong, Aditya Gorla, Noah Zaitlen, Andy W. Dahl, Sriram Sankararaman
This paper introduces REGENA, a method to disentangle gene-environment interaction mechanisms, finding that half of significant GxE signals are scale-dependent and effect heterogeneity drives most remaining GxE heritability.
medRxiv · Oct 20, 2026 · PreprintGenetic & Genomic Medicine