Zhengtong Liu

Genome-wide LD scores enable robust heritability and genetic correlation estimation from summary statistics across genetic ancestries

SUMMIT improves heritability and genetic correlation estimation across diverse ancestries using LD scores and GWAS summary statistics, showing better accuracy in non-European populations.

Disentangling phenotype scale, amplification, and effect heterogeneity underlying polygenic GxE architecture of complex traits

This paper introduces REGENA, a method to disentangle gene-environment interaction mechanisms, finding that half of significant GxE signals are scale-dependent and effect heterogeneity drives most remaining GxE heritability.

Choice of phenotype scale is critical in biobank-based GxE tests

The paper shows that phenotype scale choice affects GxE signals in biobank data, with log scaling revealing meaningful effects and explaining a significant portion of PGSxSex interactions.

Comprehensive gene heritability estimation reveals the genetic architecture of rare coding variants underlying complex traits

This paper introduces FLEX, a method for estimating gene-level heritability from whole-exome sequencing data, showing rare coding variants contribute significantly to complex trait heritability.

Scalable summary statistics-based heritability estimation method with individual genotype level accuracy

SUM-RHE estimates SNP heritability using summary statistics with accuracy comparable to individual-level methods.

A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits

The paper introduces a variance components method to estimate gene-environment interaction heritability in complex traits using UK Biobank data, finding significant GxE effects for several trait-environment pairs.

Fast Kernel-based Association Testing of non-linear genetic effects for Biobank-scale data

FastKAST detects non-linear genetic effects on traits in large datasets by providing efficient kernel-based tests with calibrated hypothesis testing.