Genetic Evaluation of the Role of Galactose-Deficient IgA1 in IgA Nephropathy: Evidence from Association Testing and Mendelian Randomization
Winston Wing‐Shing Fung, Gabriel T. Doctor, Omid Sadeghi‐Alavijeh, Jingyi Wu, Sigrid Gertrud Gisela Lundberg, Jicheng Lv, Hong Zhang, Shu‐Feng Zhou, Xue-Qing Yu, Jonathan Barratt, Daniel Philip Gale
This paper investigates the causal role of Gd-IgA1 in IgA nephropathy using genetic association and Mendelian randomization analyses, finding no significant evidence for a causal relationship.
medRxiv · Oct 25, 2025 · PreprintGenetic & Genomic Medicine