Jonathan Barratt

Genetic Evaluation of the Role of Galactose-Deficient IgA1 in IgA Nephropathy: Evidence from Association Testing and Mendelian Randomization

This paper investigates the causal role of Gd-IgA1 in IgA nephropathy using genetic association and Mendelian randomization analyses, finding no significant evidence for a causal relationship.

Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT)

PILOT uses optimal transport to analyze single-cell and pathomics data, detecting disease-associated samples and non-linear changes in cell populations and tissue structures.

From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL

CARNIVAL identifies upstream causal processes from gene expression data by integrating prior knowledge, improving accuracy over existing tools in IgA nephropathy analysis.