Levodopa increases substantia nigra iron: implications for Parkinson's disease
Guangwei Du, Luke Bransom, Mi Zhou, Christopher T. Sica, Xuemei Huang, Yang Yang, Richard B. Mailman
This study shows levodopa increases iron in the substantia nigra of rats, independent of dopamine neurons, suggesting treatment-related iron accumulation in Parkinson's disease.
bioRxiv · Jun 1, 2026 · PreprintNeuroscience