Richard B. Mailman

This study shows levodopa increases iron in the substantia nigra of rats, independent of dopamine neurons, suggesting treatment-related iron accumulation in Parkinson's disease.

This paper uses deep machine learning to identify molecular mechanisms by which levodopa affects iron metabolism in Parkinson's disease, revealing interactions with iron transporters and pathways.

The paper assesses the limitations of current methods for analyzing prefrontal cortex neural activity and proposes dynamic time warping as a potential approach for correlating neural signals with behavior.

This study links early β-amyloid accumulation in the default mode network to reduced resting-state brain activity and glymphatic function in Alzheimer's disease.

This study finds that reduced coupling between global brain activity and cerebrospinal fluid flow is associated with cognitive impairment in Parkinson's patients.

This study shows that a selective D1 dopamine agonist, dihydrexidine, significantly improves parkinsonian symptoms in severe MPTP-treated non-human primates where levodopa is ineffective.