Dynein-2 is tuned for the A-tubule of the ciliary doublet through tubulin tyrosination
Haoqiang K He, Shintaroh Kubo, Xuwei Chen, Qianru H. Lv, Azusa Kage, Muneyoshi Ichikawa
This study identifies a tyrosination-dependent mechanism that enables dynein-2 to specifically bind the A-tubule of ciliary doublet microtubules, facilitating retrograde IFT.
The EMBO Journal · Nov 26, 2025Peer-reviewedBiophysics