Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter
F. Li, J. Eriksen, J. A. Oses-Prieto, Y. K. Gomez, H. Xu, J. Finer-Moore, P. Nguyen, A. Bowen, A. Nelson, A. Burlingame, M. Grabe, R. Stroud, R. Edwards
The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.
bioRxiv · Jul 26, 2022 · PreprintBiochemistry