The mechanism of Atg15-mediated membrane disruption in autophagy
Y. Kagohashi, M. Sasaki, A. I. May, T. Kawamata, Y. Ohsumi
This study identifies Atg15 as the sole vacuolar phospholipase required for autophagic body membrane disruption, showing its activation by Pep4 and Prb1 and broad substrate specificity.
bioRxiv · Jun 26, 2023Biochemistry