A rational blueprint for the design of chemically-controlled protein switches
S. Shui, P. Gainza, L. Scheller, C. Yang, Y. Kurumida, S. Georgeon, S. Rosset, B. Correia
This paper presents a computational strategy to design chemically-controlled protein switches using drug-inhibited interactions, expanding chemical space for synthetic circuits in mammalian cells.
bioRxiv · Jan 21, 2021Biochemistry