Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms
A. M. Cardozo Gizzi, D. I. Cattoni, J.-B. Fiche, S. Espinola, J. Gurgo, O. Messina, C. Houbron, Y. Ogiyama, G.-L. Papadopoulos, G. Cavalli, M. Lagha, M. Nollmann
The paper introduces Hi-M, a microscopy-based method to simultaneously visualize genome organization and transcription in single nuclei of Drosophila embryos, revealing changes in 3D chromatin structure during transcriptional activation.
bioRxiv · Jan 21, 2019Cell Biology