Liquid-liquid phase separation of full-length prion protein initiates conformational conversion in vitro
H. Tange, D. Ishibashi, T. Nakagaki, Y. Taguchi, Y. O. Kamatari, H. Ozawa, N. Nishida
This study shows that liquid-liquid phase separation of rPrP initiates conformational conversion to PrP-res in vitro, with key roles for the N-terminal region and kosmotropic salts.
bioRxiv · Jan 25, 2020Biochemistry