Loss of 20-HETE-GPR75 Signaling Impairs Renal Hemodynamic Adaptation in Sepsis
Yaqi Han, Huaxing Zhang, Leying Li, Lixia Liu, Yanling Yin, Yuhong Chen, Xin Lin, Ruike Yang, Congcong Zhao, Zhenjie Hu
This study investigates the role of 20-HETE-GPR75 signaling in sepsis-induced renal dysfunction and finds that its loss impairs renal hemodynamics and contributes to acute kidney injury.
bioRxiv · Sep 21, 2026 · PreprintPathology