Author

Yanshen Yang

Illumina (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Organism:multiple species· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Anne O’Donnell‐LuriaiD· 2 shared François AguetiD· 2 shared Heidi L. RehmiD· 2 shared Hong Chao GaoiD· 2 shared Jeffrey RogersiD· 2 shared Jeremy F. McRaeiD· 2 shared Joshua G. SchraiberiD· 2 shared Kyle Kai‐How FarhiD· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Anne O’Donnell‐LuriaORCID

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Author profile →

2 papers

Recent·Most cited

The landscape of tolerated genetic variation in humans and primates

Hong Chao Gao, Tobias Hamp, Jeffrey M. Ede, Joshua G. Schraiber, Jeremy F. McRae, Moriel Singer‐Berk, Yanshen Yang, Anastasia S. D. Dietrich, Petko P. Fiziev, Lukas F. K. Kuderna, Laksshman Sundaram, Yibing Wu, Aashish N. Adhikari, Yair Field, Chen Chen, , Kyle Kai‐How Farh

The paper uses primate genetic data to predict human variant pathogenicity with a deep learning classifier trained on 4.3 million common missense variants.

Science · Jun 1, 2023Peer-reviewedGenomics

Rare penetrant mutations confer severe risk of common diseases

Petko P. Fiziev, Jeremy F. McRae, Jacob C. Ulirsch, Jacqueline S. Dron, Tobias Hamp, Yanshen Yang, Pierrick Wainschtein, Zijian Ni, Joshua G. Schraiber, Hong Chao Gao, Dylan M. Cable, Yair Field, François Aguet, Marc Fasnacht, Ahmed A. Metwally, , Kyle Kai‐How Farh

The paper identifies rare variant polygenic risk scores as more effective than common variant polygenic risk scores in identifying individuals with outlier phenotypes in common human diseases and complex traits.

Science · Jun 1, 2023Peer-reviewedGenetic & Genomic Medicine