Toward Best Practice in Identifying Subtle Differential Expression with RNA-seq: A Real-World Multi-Center Benchmarking Study Using Quartet and MAQC Reference Materials
Duo Wang, Yaqing Liu, Yuanfeng Zhang, Qingwang Chen, Yanxi Han, Wanwan Hou, Cong Liu, Yin Yu, Ziyang Li, Ziqiang Li, Jiaxin Zhao, Yuanting Zheng, Leming M. Shi, Jinming Li, Rui Zhang
This study benchmarks RNA-seq methods across 45 labs to identify sources of variation in detecting subtle differential expression, highlighting experimental and bioinformatics factors affecting reliability.
bioRxiv · Dec 9, 2023 · PreprintGenomics