Wanwan Hou

The paper introduces Plasmix, a plasma reference suite, to improve cross-platform proteomics integration by identifying proteins with consistent titration responses across platforms.

This study identifies CtaA as a regulator of H2S production and virulence in S. aureus by linking metabolic reprogramming to redox defense under glucose-depleted conditions.

This paper develops a ratio-based framework using Quartet reference materials to integrate long- and short-read RNA-seq data, showing hybrid-seq achieves the highest quantification accuracy.

This study benchmarks RNA-seq methods across 45 labs to identify sources of variation in detecting subtle differential expression, highlighting experimental and bioinformatics factors affecting reliability.

This paper introduces Quartet DNA reference materials to comprehensively evaluate germline variant calling accuracy across the genome, including difficult regions and batch effects.

The paper evaluates seven batch-effect correction algorithms for multiomic data and finds the ratio-based method is more effective, especially when batch effects are confounded with biological factors.

This study compares transcriptomic profiles of whole blood, plasma-free blood, and serum-free blood samples, finding that plasma-free blood is more similar to whole blood in gene expression and immune characterization.

The paper establishes reference materials and methods to assess inter-laboratory reliability and data integration in metabolomic profiling.

This paper introduces ratio-based multiomics profiling using universal reference materials to improve data integration across omics types and batches.

The paper introduces RNA reference materials and ratio-based datasets to improve the reliability and benchmarking of transcriptomic profiling.