Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD
Rachel Coneys, Alexander J. Cammack, R. Nair, David Thompson, Jonas Mechtersheimer, Mireia Carcolé, Yashica Gupta, Gabriel Eduardo Rech, Michael D. Flower, Niamh Louise O’Brien, Marc‐David Ruepp, Sarah Mizielinska, Fiona Ducotterd, Sarah J. Tabrizi, Elizabeth Fisher, , Adrian M. Isaacs
The paper describes the generation and validation of C9orf72 repeat expansion knock-in iPSC lines for ALS and FTD research, showing they differentiate into neurons and display disease-related pathologies.
bioRxiv · Feb 10, 2025 · PreprintNeuroscience