Canonical self-supervised pretraining paradigm constrains the capacity of genomic language models on regulatory decoding
Ye-Xi Liang, Yu Wang, Wang-Yue Pan, Ziyu Chen, Jiachen Wei, Ge Gao
This study evaluates 11 genomic language models and finds they offer limited advantages over a random baseline in regulatory decoding tasks.
bioRxiv · Apr 16, 2026 · PreprintBioinformatics