BioengineeringbioRxivPreprint
NPlasmid-seq: Cas9-encoded terminal signatures enable molecule-level nanopore quality control of vector and IVT-template plasmids
Yan Xu, Wei Wen, Di Sun…·Jian-Ping Zhang
NPlasmid-seq detects sub-percent contamination and sequence heterogeneity in plasmid preparations using Cas9-encoded terminal signatures, revealing structural variants missed by consensus-based methods.
DOI 10.64898/2026.11.02.763549