SND1 Impairs Calcium Homeostasis in Right Ventricular Failure by Binding and Destabilizing SERCA2a in Cardiomyocytes
Lizhe Guo, Xingyang Liu, Lu Wang, Yinqi Li, Xiaocheng Zhu, Cheng Xu, Chunyan Ye, Na Chen, Longyan Li, Gang Qin, Yanfeng Wang, Dandan Wang, Jian Qiu, E Wang
This study identifies SND1 as a reactivated fetal gene that contributes to right ventricular failure by destabilizing SERCA2a, impairing calcium handling, and reducing cardiomyocyte contractility and survival.
bioRxiv · Apr 14, 2025 · PreprintCell Biology