A comparative study of statistical methods for identifying differentially expressed genes in spatial transcriptomics
Yishan Wang, Chenxuan Zang, Ziyi Li, Charles Chuanhai Guo, Dejian Lai, Peng Wei
This paper compares statistical methods for differential gene expression in spatial transcriptomics, finding that the GEE framework better controls false positives than the Wilcoxon test.
PLoS Computational Biology · Feb 11, 2026Peer-reviewedBioinformatics