Charles Chuanhai Guo

TUSCAN improves tumor region identification in spatial transcriptomics by integrating copy number variation profiles with histopathological images.

This paper compares statistical methods for differential gene expression in spatial transcriptomics, finding that the GEE framework better controls false positives than the Wilcoxon test.

This study identifies molecular changes in bladder mucosa that initiate cancer, revealing inflammation's role and mutation patterns linked to early carcinogenesis.

This study identifies distinct genomic and molecular features of sarcomatoid bladder cancer, linking EMT dysregulation to aggressive behavior and immune infiltration.