Author

Yixuan Liu

Broad Institute

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Biology Disciplines

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Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Research Focus:polygenic risk· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Akl C. FahediD· 1 shared Andrew Chan· 1 shared Kaavya ParuchuriiD· 1 shared Linke LiiD· 1 shared M Kim· 1 shared Michael C. HonigbergiD· 1 shared Nilanjan ChatterjeeiD· 1 shared Pradeep NatarajaniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Akl C. FahedORCID

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1 paper

Recent·Most cited

Evaluating Individual Level Performance of Polygenic Risk Scores Using Early Onset High Genetic Risk Coronary Artery Disease as a Benchmark

梁圣心, M Kim, Yang Sui, Youxin Tan, Linke Li, So Mi Jemma Cho, Satoshi Koyama, Yixuan Liu, Kaavya Paruchuri, Andrew Chan, Michael C. Honigberg, Pradeep Natarajan, Nilanjan Chatterjee, Akl C. Fahed, Zhi Yu

The paper evaluates individual-level performance of polygenic risk scores (PRSs) using a benchmark cohort of early-onset coronary artery disease patients, showing variability in PRS accuracy and highlighting the need for individual-level validation.

medRxiv · Apr 18, 2026 · PreprintGenetic & Genomic Medicine