Akl C. Fahed

This study evaluates polygenic risk scores for cardiovascular diseases in predicting carotid stenosis, finding that PAD and CAD PRSs show significant associations and improved discrimination over traditional risk factors.

The paper evaluates individual-level performance of polygenic risk scores (PRSs) using a benchmark cohort of early-onset coronary artery disease patients, showing variability in PRS accuracy and highlighting the need for individual-level validation.

The paper evaluates the instability of polygenic risk scores (PRS) across different publications and introduces an integrative scoring framework to improve classification consistency.

The paper designs and tests a polygenic score report for coronary artery disease, identifying user preferences for visual elements, risk communication, and personalized resources.

This paper integrates monogenic, polygenic, and clinical risk factors to predict disease risk for carriers of rare variants, identifying elevated risk in 18.22% of UK Biobank participants for breast cancer, familial hypercholesterolemia, and colorectal cancer.

The paper examines how polygenic risk modifies the penetrance of monogenic variants in coronary artery disease, breast cancer, and colorectal cancer across multiple cohorts.