Mucosal Inflammation as a Driver of Gd-IgA1 Production in IgA Nephropathy: Mechanistic Support for Targeted Therapies
Kateřina Zachová, Alica Cutkova, Petr Kosztyu, Yukako Ohyama, Kazuo Takahashi, Josef Zadražil, Jiří Orság, Naděžda Petejová, Dana Galuszková, Jiri Mestecky, Milan Raška
This study shows mucosal cytokines drive Gd-IgA1 production in IgAN by expanding specific B cell populations, supporting therapies targeting mucosal immunity.
bioRxiv · Oct 24, 2026 · PreprintImmunology