Minocycline engages microglia in the midbrain periaqueductal grey to attenuate hypoxia-triggered panic-like behaviour in rats
Arthur Rocha‐Gomes, Jefferson Manoel Nascimento‐Silva, Beatriz Cassimiro Baratella, Beatriz Dominiquini-Moraes, Yurie Sato, Erika Meyer, Sabrina Francesca de Souza Lisboa, Norberto Cysne Coimbra, Luciane H. Gargaglioni, Valentina Mosienko, Hélio Zangrossi
This study shows that minocycline reduces panic-like behavior in rats exposed to hypoxia by preventing microglial morphological changes in the midbrain periaqueductal grey.
bioRxiv · Aug 2, 2026 · PreprintNeuroscience