Dibenzoylmethane, a novel β-diketone pore blocker of large-conductance calcium-activated potassium channel
Piotr Koprowski, Przemysław Miszta, Jakub Władysław Strawa, Yurii Krempovych, Alicja Ziajowska, Sławomir Filipek, Adam M. Szewczyk, Michał Tomczyk
This study identifies dibenzoylmethane (DBM) as a novel inhibitor of BKCa channels, showing it blocks the pore and alters ion dynamics, with structural features critical for activity.
bioRxiv · Apr 28, 2026 · PreprintPharmacology & Toxicology