Extracellular stiffness regulates cell fate determination and drives the emergence of evolutionary novelty in teleost heart
Sho Matsuki, Yusei Inoue, Ryuta Watanabe, Toshiyuki Mitsui, Yuuta Moriyama
The paper shows that extracellular stiffness regulates cell fate in the teleost heart, with elastin b conferring low stiffness to the bulbus arteriosus, driving evolutionary novelty.
Proceedings of the National Academy of Sciences · Feb 19, 2026Peer-reviewedDevelopmental Biology