m6A methylation regulates RNA axonal localisation and translation in developing neurons
Braulio Martinez De La Cruz, Simon Galkin, Shiqi Wang, Yuxuan Jing, Subramanian Raju Nurani, Pierre-Luc Germaine, Gerhard M. Schratt, Antonella Riccio
This study shows that m6A methylation regulates RNA transport and local translation in axons of developing neurons, with NGF promoting methylated transcript localization and inhibiting premature protein synthesis.
bioRxiv · Sep 1, 2025 · PreprintNeuroscience