Gerhard M. Schratt

The paper identifies miR-1229-3p as a human-specific microRNA that delays neuronal synaptogenesis by reducing mitochondrial metabolism.

The paper predicts transcription factor binding across 43 human cell types using ATAC-seq data and a new platform, revealing promiscuous occupancy and chromatin contacts.

The paper shows that inhibiting miR-495-3p in mice rescues mTORC1 hyperactivation-driven autistic-like behaviors and memory impairments.

This study shows that m6A methylation regulates RNA transport and local translation in axons of developing neurons, with NGF promoting methylated transcript localization and inhibiting premature protein synthesis.

This study shows that miR-138-5p suppresses excitatory synaptic strength in the cerebellum by affecting both pre- and postsynaptic mechanisms.

This study identifies miR-218-5p as a regulator that coordinates excitatory and inhibitory synaptic scaling during homeostatic synaptic plasticity and sleep.

The paper identifies circRNAs that regulate excitatory synaptogenesis in rat hippocampal neurons by modulating miR-128-3p activity.

This study shows that miR-379-410 regulates sociability in mice by inhibiting an actomyosin network, with implications for neurodevelopmental disorders.

The paper identifies miR-708-5p as a biomarker for bipolar disorder and shows its role in regulating mood disorder-associated behaviors through targeting Nnat.

The paper investigates whether circular or linear RNA topology affects Target RNA-Directed MicroRNA Degradation (TDMD), finding that circular RNAs can inhibit while linear forms can drive TDMD.

This study identifies miR-138-5p as a regulator of short-term memory and inhibitory synaptic transmission in hippocampal interneurons, with implications for schizophrenia.

The paper identifies miR-329 and miR-495 as regulators of Prr7 downregulation, which is necessary for homeostatic synaptic depression in rat hippocampal neurons.

scanMiR predicts microRNA targets using a biochemical model and k-mer affinity, offering tools for binding site scanning, affinity estimation, and repression prediction.

This study identifies compartment-specific gene expression changes during synaptic scaling in rat hippocampal neurons, revealing distinct regulatory mechanisms in somatic and process compartments.

This study identifies miR-499-5p as a regulator of neuroplasticity in bipolar disorder by targeting CACNB2, leading to impaired dendritogenesis and cognitive function.

diffUTR is a Bioconductor package that improves differential exon and 3' UTR usage analysis by integrating existing tools and databases, showing better flexibility and accuracy.

The paper profiles miRNAs in mouse cortical progenitors and neurons, identifying miR-486-5p as a novel regulator of neurogenesis.