Accounting for gene action improves the accuracy of polygenic scores for some complex traits
Yuxuan Sun, Fabio Morgante, Trudy F. C. Mackay
This study introduces PGSa,d, a polygenic scoring framework that incorporates both additive and dominance effects, showing improved accuracy for traits with significant dominance contributions.
medRxiv · Oct 19, 2026 · PreprintGenetic & Genomic Medicine