Trudy F. C. Mackay

This study introduces PGSa,d, a polygenic scoring framework that incorporates both additive and dominance effects, showing improved accuracy for traits with significant dominance contributions.

This study identifies genetic variants associated with cocaine consumption and preference in Drosophila melanogaster, revealing potential human orthologs linked to substance use disorders.

The paper evaluates gene-environment interactions in blood pressure traits across diverse populations and finds they explain additional variance, though they do not improve prediction accuracy.

The paper uses multiome sequencing to show prenatal heat call exposure in zebra finch embryos alters astrocyte and neuroendocrine gene regulation in the hypothalamus.

The paper introduces DGRP3, an expanded Drosophila genetic reference panel with 1,233 inbred lines, identifying genetic variants and performing GWAS for traits like inbreeding depression and sensory bristles.

This study investigates how genetic variation affects phenotypic responses to diet and aging in Drosophila melanogaster, finding significant genotype-by-diet and genotype-by-age interactions.

This study examines arsenic toxicity in Drosophila brains using single-nuclei RNA sequencing, revealing sex-specific transcriptional responses and linking findings to human neurogenetic networks.

The paper identifies genetic variants and genes associated with mating success between DGRP males and Zimbabwe females, revealing polygenic and inversion-based mechanisms of incipient sexual isolation in Drosophila melanogaster.

This study uses Drosophila models to analyze gene expression and behavior changes in chromatin modification disorders, identifying co-regulated genes and potential therapeutic targets.

This study identifies genes and pathways that interact with early-life nutrition to influence sleep behavior and brain morphology in Drosophila.

This study investigates the pleiotropic effects of the lncRNA Uhg4 in Drosophila melanogaster by generating deletions and analyzing fitness traits and gene expression.

The paper develops a Drosophila model for Fetal Alcohol Spectrum Disorder and finds that developmental alcohol exposure modulates gene and non-coding RNA networks related to nervous system development and ethanol metabolism.

This study examines the physiological and metabolomic effects of reduced brummer lipase expression in Drosophila, revealing sexual dimorphism and metabolic changes relevant to human disorders.

This study examines the effects of developmental alcohol exposure on adult Drosophila phenotypes and brain gene expression, revealing sexual dimorphism and similarities to cocaine-induced gene expression changes.

The paper investigates how single nucleotide polymorphisms in the Drosophila Obp56h gene affect quantitative traits and molecular phenotypes, finding that allelic effects are context-dependent and not captured by traditional additive models.

This study identifies genetic variants associated with cocaine and methamphetamine consumption in Drosophila, revealing polygenic and sex-specific effects involving nervous system genes.

This study predicts Drosophila complex traits using genotypes, gene expression, and gene ontology, finding that expression and GO terms improve accuracy, especially when sample sizes are small.

This study examines how genetic variation in gene expression responds to environmental changes in Drosophila melanogaster, finding genotype by environment interactions and conserved co-expression networks.

The paper maps expression quantitative trait loci and constructs sex-specific regulatory networks in Drosophila to understand how genetic variation affects gene expression and transposable element activity.

This study identifies genetic and neural factors influencing cocaine and methamphetamine consumption in Drosophila melanogaster using natural genetic variation and RNAi knockdown.