Identification of Bone Morphogenetic Protein 7 as a Master Regulator of Gastric Cancer-Associated Cachexia
Mayu Yasuda-Koiwa, Takahiro Shoda, Akiho Nishimura, Tadahito Yasuda, Atsuko Yonemura, Kota Muraki, Yuya Okamoto, Takuya Tajiri, Yanru Wang, Takatsugu Ishimoto
In a gastric cancer peritoneal dissemination mouse model, BMP7 knockdown in MKN45 cells attenuated cachexia, and BMP7 acted upstream of GDF11 and GDF15 expression.
bioRxiv · Jul 21, 2026 · PreprintCancer Biology✦ In-depth digest