Heuristic Multi-site Optimization for Protein Sequence Design using Masked Protein Language Models
Lijuan Wang, Yuze Wang, Qiu Chen, Li Xiao, Xianliang Liu, Junjie Chen
This paper introduces ProtHMSO, a heuristic multi-site optimization framework using masked protein language models to design functional protein sequences more efficiently than existing methods.
PLoS Computational Biology · Jun 5, 2026Peer-reviewedBioinformatics