Chromosome Ageing Occurs at the Primordial Follicle Stage in both Mouse and Human Oocytes
Matilda Bui, Apiwat Moolnangdeaw, Hannes Becher, Shelagh Boyle, Vlastimil Sršeň, Yvonne L. Odey, Richard A. Anderson, Evelyn E. Telfer, Ian R. Adams
The paper shows that chromosome ageing, marked by increased chromatid separation and cohesin depletion, occurs in primordial follicles in both mouse and human oocytes.
bioRxiv · Jul 17, 2025 · PreprintDevelopmental Biology