Cancer BiologybioRxivPreprint
An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development
Athina Varveri, Miranta Papadopoulou, Zacharias Papadovasilakis…·Panayotis Verginis
This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.
DOI 10.1101/2023.12.22.572969