Benchmarking the Performance of a Commercial Electrostatic Linear Ion Trap (ELIT) Charge Detection Mass Spectrometer For Higher-Order Antibody Aggregate Analysis
Shang-Yin Wu, Xing-Miao Guo, Jia-Yi Lv, Yingzi Li, Lei Gu, Zachary Tian, Yongsheng Xiao, Emily Christofi, Anisha Haris, Haoyun Lu, Rui Wang, Huan-Fang Xie, Hongwen Li, Pan Yuanjiang, Mowei Zhou, Wei‐Jie Fang
This study evaluates a commercial CDMS platform for analyzing higher-order antibody aggregates, showing its ability to measure mass and charge with high precision and differentiate complex ion populations.
bioRxiv · Oct 15, 2026 · PreprintBiochemistry