Endothelin 3 and T-type Ca2+ channels drive enteric neural crest cell calcium activity, contractility and migration
Nicolas R. Chevalier, Fanny Gayda, Nadège Bondurand, Ze Chi Chan, Thierry Savy, Monique Frain, Amira El Merhie, Lenuta Canta, Monica Dicu, Isabelle Eude-Le Parco, Léna Zig
This study shows that endothelin 3 and T-type Ca2+ channels regulate calcium activity, contractility, and migration of enteric neural crest cells, linking these processes to Hirschsprung disease.
Nature Communications · Jan 20, 2026Peer-reviewedDevelopmental Biology